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Inflammatory Dermatoses: The Basics - download pdf or read online

By Bruce R. Smoller

ISBN-10: 1441960031

ISBN-13: 9781441960030

ISBN-10: 144196004X

ISBN-13: 9781441960047

Inflammatory Dermatoses: the fundamentals will function a good and effective guide for the scholar of dermatopathology, and as a realistic bench reference for the practising diagnostician who wishes swift entry to standards which are helpful in differentiating histologically related entities. The chapters encompass crucial bullet issues prepared in geared up outlines taking into consideration quick access and direct comparability among entities. the flowery pictorial documentation also will allow the e-book to function an atlas of the most typical dermatologic disorders.

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20 Radiation fibroblasts, characterized by hyperchromasia, pleomorphism, and florid cytologic atypia, are seen coursing through the sclerotic dermis. Original magnification 200× 38 2 Lichenoid/Vacuolar Dermatitis • Pityriasis lichenoides (chronica) (PLC) – Clinical ◦ Multiple papules on trunk and extremities with overlying scale ◦ Ulceration not frequent ◦ Often in adolescents/young adults ◦ Papules at all stages of development concurrently ◦ Relatively asymptomatic – Histologic ◦ Superficial perivascular lymphoid infiltrate with exocytosis ◦ Basal vacuolization and rare dying keratinocytes ◦ Eosinophils rare ◦ Overlying parakeratosis ◦ Scant dermal and epidermal hemorrhage ◦ Parakeratosis helps distinguish from erythema multiforme (Figs.

27) • Lichenoid drug eruption – Clinical ◦ Lesions resemble lichen planus ◦ Often can be associated temporarily with initiation of new medication (long list of implicated drugs) – Histologic ◦ Differs from LP by potential presence of eosinophils, deeper infiltrate, and parakeratosis ◦ None of these features are invariably present, so may be impossible to distinguish without clinical history (Figs. 29) Fig. 25 Lichen planus is characterized by a flat-topped papule with overlying orthokeratotic hyperkeratosis.

8 Grade III GVHD is characterized by a subepidermal blister with dying keratinocytes and a mild lymphocytic infiltrate. Original magnification 200× Fig. 9 The lichenoid variant of chronic GVHD is often indistinguishable histologically from lichen planus and requires clinical correlation. There is a band-like infiltrate of lymphocytes, a subepidermal separation, and an acanthotic epidermis, often with hypergranulosis. Original magnification 100× 30 2 Lichenoid/Vacuolar Dermatitis Fig. 10 Sclerodermatoid chronic GVHD is quite similar to scleroderma with loss of appendages, dermal sclerosis, and a minimal inflammatory infiltrate.

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Inflammatory Dermatoses: The Basics by Bruce R. Smoller


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